ACCELERATOR FOR BLOOD PLATELET AGGREGATION INHIBITION AND DISSOCIATION DERIVED FROM BLOOD AND ITS PREPARATION

摘要

NEW MATERIAL:An accelerator for blood platelet aggregation inhibition and dissociation containing a fraction having a partition coefficient (Kav) of 0.65-1.05 in gel filtration with Sephadex G-25 (trade name of dextran gel, Pharmacia Fine Chemical Co.) of blood plasma or serum of a mammal as an active constitutent. Appearance: White powder (dried product). Solubility: readilysoluble in water; slightly soluble in alcohol, chloroform, etc. Aqueous solution: Weakly alkaline of pH8-10. Thermal stability: Stable activity by heating an aqueous solution thereof at 100 deg.C for 20min; stable activity by heating a solution in 1N. hydrochloric acid or sodium hydroxide at 100 deg.C for 20min. USE:A remedy and a preventive for thrombosis, e.g. cardiac infarction, cerebral thrombosis or intravascular blood coagulation syndrome and insufficiency, e.g. renal insufficiency, arising therefrom. PROCESS:Blood plasma or serum of a mammal is dialyzed, and the component passing through a membrane is fractionated by the method as described above.