1,2,4-Triazole derivatives, processes for their production and pharmaceutical compositions containing them.

摘要

The invention relates to compounds of the general formula (I) CHEM and physiologically acceptable salts, hydrates and bioprecursors thereof, in which R1 and R2, which may be the same of different, each represent hydrogen, C1-10 alkyl, cycloalkyl, alkenyl, alkynyl, aralkyl, trifluoroalkyl, or alkyl substituted by hydroxy, alkoxy, amino, alkylamino dialkylamino or cycloalkyl or R1 and R2 may together with the nitrogen atom to which they are attached form a 5 to 10 membered ring which may be saturated or may contain at least one double bond, may be unsubstituted or may be substituted by one or more C1-3 alkyl groups or a hydroxy group and/or may contain another heteroatom which is oxygen or sulphur Alk represents a straight or branched alkylene chain of 1 to 6 carbon atoms, Q represents a furan or thiophene ring in which incorporation into the rest of the molecule is through bonds at the 2- and 5- positions, the furan ring optionally bearing a further substituent R6 adjacent to the group R1R2N-Alk, or Q represents a benzene ring in which incorporation into the rest of the