A method of preparing an inhibitor of angiotensin converting enzyme-

摘要

Inhibitors of angiotensin converting enzyme which are physiologically tolerated salts of compounds of the general formula (I) in which R is hydrogen, formyl, acetyl, propanoyl, butanoyl, phenylacetyl, phenylpropanoyl, benzoyl, cyclopentanecarbonyl, tert- butyloxycarbonyl, cyclopentanecarbonyl-L-lysyl, pyro-L- glutamyl-L-lysyl, L-lysyl, L-arginyl or pyro-L-glutamyl, A is phenylalanyl, glycyl, alanyl, tryptophyl, tyrosyl, isoleucyl, leucyl, histidyl or valyl, where the alpha- amino group of these radicals is bonded in the form of an amide bond to the radical R having a meaning other than hydrogen, and phenylalanyl is racemic if R is benzoyl, R1 is hydrogen or methyl, R2 -COOH, L-proline, L-3,4- dehydroproline, D,L-3,4-dehydroproline, L-3- hydroxyproline, L-4-hydroxyproline, L-thiazolidine-4- carboxylic acid or L-5-oxoproline, where the imino group in these radicals is bonded to the adjacent group, Kat is the cation of a base, and n is zero or 1, where R1 is methyl if n is zero. IMAGE