Basic ethers of the formula IMAGE wherein Z is CH3-NR2-CH2CH2-CHR1-, (1-R2-3-piperidyl)-CHR3-, (1-R2-2-piperidyl)-CH2-CHR3- or 1-R2-3-R4-hexahydroazepinyl; R1 is cyclopropyl or Ar; R2 is H, alkyl of 1-4 C atoms, alkenyl of 2-4 C atoms, cycloalkylalkyl of 4-8 C atoms or benzyl; R3 is H or Ar; R4 is H or alkyl of 1-4 C atoms, Y is -O-CHQ1-CHQ2-CH2-, -O-CHQ1-CHQ2-CO-, -O-CQ1=CQ2-CO- or -CH2-CHQ1-CHQ2-CO-; Q1 and Q2 are independently each H, alkyl of 1-4 C atoms, cycloalkyl or alkylcycloalkyl each of 3-6 total C atoms or Ar; and Ar is phenyl or phenyl substituted by F, Cl, alkoxy or alkylthio, each of 1-4 C atoms, methylenedioxy or CF3; with the proviso that when Z is (CH3 )2N-CH2CH2-CHR1 in 7-position and Y is -O-C(C6H5)=CH-CO- or -O-C(C6H5)=C(CH3)-CO-, R1 is cyclopropyl, or phenyl substituted by F, Cl, alkoxy or alkylthio, each of 1-4 C atoms, methylenedioxy or CF3; or a physiologically acceptable acid addition salt thereof, have valuable pharmacological properties, e.g., are antidepressants.
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机译:式的碱性醚,其中Z为CH3-NR2-CH2CH2-CHR1-,(1-R2-3-哌啶基)-CHR3-,(1-R2-2-哌啶基)-CH2-CHR3-或1- R2-3-R4-六氢a庚啶基; R1为环丙基或Ar; R 2为H,1-4个碳原子的烷基,2-4个碳原子的烯基,4-8个碳原子的环烷基烷基或苄基; R3为H或Ar; R 4是H或1-4个碳原子的烷基,Y是-O-CHQ1-CHQ2-CH2-,-O-CHQ1-CHQ2-CO-,-O-CQ1 = CQ2-CO-或-CH2-CHQ1-CHQ2 -CO-; Q1和Q2各自独立地为H,1-4个碳原子的烷基,总C原子数为3-6的环烷基或烷基环烷基或Ar; Ar为苯基或被1-4个碳原子的F,Cl,烷氧基或烷硫基取代的苯基或亚甲基二氧基或CF3;前提是Z在7位为(CH3)2N-CH2CH2-CHR1且Y为-OC(C6H5)= CH-CO-或-OC(C6H5)= C(CH3)-CO-时,R1为环丙基;或被F,Cl,烷氧基或烷硫基取代的苯基,分别为1-4个碳原子,亚甲二氧基或CF3;或其生理上可接受的酸加成盐,具有有价值的药理特性,例如抗抑郁药。
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