SUBSTITUTED BENZONITRILES AND METHOD AND COMPOSITION FOR INHIBITING VIRUSES

摘要

Substituted benzonitriles are disclosed having the formula IMAGE wherein X represents O or S; R1 represents bromo, chloro, fluoro, phenoxy, loweralkylthio, loweralkylsulfinyl, loweralkylsulfonyl, loweralkylaminosulfonyl, diloweralkylaminosulfonyl or benzoyl; and R2 represents hydrogen, bromo, chloro or fluoro with the proviso that R2 is hydrogen when R1 is a substituent other than bromo, chloro or fluoro. The compounds of the invention exhibit antiviral activity. Methods of use based on the antiviral activity of the compounds are also disclosed, as well as compositions which comprise a carrier in combination with a suitable antiviral active compound.