A process for the preparation of a stable Concentrated solution of Cisplatin

摘要

Preparation method of concentrated Solution Stable cisplatin. Consists in preparing a Solvent comprising a 30 - 95 percent of polyethylene glycol of Molecular weight between 150 and 9000, or methoxy polyethylene glycol of Molecular weight between 300 and 6.000, or a mixture of both, with a 5 - 70 percent of water source and no toxic and farmaceuticmente acceptable chloride ion in an amount equivalent to that of Cisplatin, and dissolve in the same amount of Cisplatin enough to achieve a concentration of 2.5 to 25 mg / ml, so wue is produzc Corresponding to the complexation reaction.The source of chloride ion can be mgci HCI naci, CACI, or a mixture thereof. Several variants are available with different proportions and Average Molecular Weights of the components of the Solvent, as well as the amount of Cisplatin