首页>
外国专利>
FRAMEWORK FOR THE PHARMACOLOGICAL PROCESSING OF THE PHARMACOLOGICAL NETWORK I 5-ELLER 6-STATIONARY MEDIUM PYRIDAZINONRING SUBSTITUERADE BESIMIDAZOLER
FRAMEWORK FOR THE PHARMACOLOGICAL PROCESSING OF THE PHARMACOLOGICAL NETWORK I 5-ELLER 6-STATIONARY MEDIUM PYRIDAZINONRING SUBSTITUERADE BESIMIDAZOLER
展开▼
机译:药理学网络的药理学框架I 5级6阶吡嗪叠氮中取代苯并咪唑类药物
展开▼
页面导航
摘要
著录项
相似文献
摘要
Compounds of the formula IMAGE wherein R1 is hydrogen; trifluoromethyl; alkyl of 1 to 11 carbon atoms; cycloalkyl of 3 to 7 carbon atoms; hydroxyl; alkoxy of 1 to 6 carbon atoms; mercapto; (alkyl of 1 to 6 carbon atoms)-mercapto; phenyl-(alkyl of 1 to 3 carbon atoms); phenyl; or mono-, di- or tri-substituted phenyl, where the substituents, which may be identical to or different from each other, are each halogen, alkyl of 1 to 4 carbon atoms, (alkyl of 1 to 6 carbon atoms)-sulfinyl, hydroxyl, alkoxy of 1 to 6 carbon atoms, mercapto or (alkyl of 1 to 6 carbon atoms)-mercapto; R2 is hydrogen, alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 6 carbon atoms or phenyl-(alkyl of 1 to 3 carbon atoms); and R3 is alkyl of 1 to 6 carbon atoms; optically active antipodes thereof; and non-toxic, pharmaceutically acceptable acid addition salts of said compounds or of said optically active antiposed. The compounds are useful as cardiotonics and antithrombotics.
展开▼
机译:式的化合物,其中R1是氢;三氟甲基; 1至11个碳原子的烷基; 3至7个碳原子的环烷基;羟; 1-6个碳原子的烷氧基;巯基(1至6个碳原子的烷基)-巯基;苯基-(1-3个碳原子的烷基);苯基或单,二或三取代的苯基,其中可以彼此相同或不同的取代基分别是卤素,1-4个碳原子的烷基,(1-6个碳原子的烷基)-亚磺酰基,羟基,1-6个碳原子的烷氧基,巯基或(1-6个碳原子的烷基)-巯基; R 2为氢,碳数为1至6的烷基,碳数为3至6的环烷基或苯基-(碳数为1至3的烷基); R 3为碳数1〜6的烷基。其旋光对映体;以及所述化合物或所述旋光活性的无毒的药学上可接受的酸加成盐。该化合物可用作强心药和抗血栓药。
展开▼