Certain 7-acylamido-3-(2-carboxyalkyl-2,3-dihydro-s-triazolo 4,3- b!pyridazin-3-on-6-ylmethyl)-3-cephem-4-carboxylic acids their salts and easily hydrolyzed esters

摘要

New amino-3-(2-carboxyalkyl-2,3-dihydro-3-oxo-s-triazolo[4,3-b]pyridazin-6 -ylthiomethyl)-3-cephem-4-carboxylic acids of formula I, their salts and their easily hydrolysed esters of the 4-carboxyl group are prepared. The synthesis consists in reacting a compound of formula III with a compound of formula IV and then treating the product obtained with an acylating agent R2-X. The compounds of the invention are powerful antibacterial agents which have a good solubility in water. IMAGE