The invention provides novel prostaglandin compounds and processes for the preparation thereof which are prostaglandins of the E, F, or A series having on the terminal methylene carbon of the alpha chain a substituent selected from the group consisting of CHEM wherein R is an alkyl group and R15 is C1-C4 alkyl, di-C1-C4-alkylamino and phenyl or phenyl substituted with one or more substituents selected from the group consisting of C1-C4 alkyl, OR, SR, F or C1 wherein R is as previously defined. Processes for the preparation of these compounds are described as well as pharmaceutical compositions containing them. The compounds have a potential utility in medicine as for example: hypotensive agents, anti-ulcer agents and bronchodilators.
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