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CNS-Depressant pyrazolopyridines

机译:中枢神经系统抑制剂吡唑并吡啶

摘要

Compounds of the formula (I): IMAGE I wherein R1, R3, R4, R7 and R8 are as described herein, D is oxygen or NR6, n is 1 or 2 and the physiologically acceptable salts thereof useful in reducing anxiety in an animal such as man. The compounds are potent anxiolytics having reduced side effects compared to known anxiolytics. Also pharmaceutical compositions, intermediates and methods of treatment and synthesis are described.
机译:式(I)的化合物:式I,其中R 1,R 3,R 4,R 7和R 8如本文所述,D为氧或NR 6,n为1或2,其生理上可接受的盐可用于减轻动物体内的焦虑感。动物如人。与已知的抗焦虑药相比,该化合物是具有降低的副作用的有效抗焦虑药。还描述了药物组合物,中间体以及治疗和合成方法。

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