A process for the preparation of hydrogen Receptor Antagonists of Histamine.

摘要

Method for preparing H2 Receptor Antagonists of Histamine, of General formula (i), in which R is Hydrogen, Lower alkyl or propargilo; M is 0, 1 or 2, N is 2, 3, 4, 5; Z is Oxygen, Sulfur or methylene is a; and radical, and their pharmaceutically acceptable salts notoxicas, Tables.Involves reacting a compound of formula (ii) at least one Equivalent molar, preferably with a molar excess of Sulfur MONOCHLORIDE SULFUR DICHLORIDE, or a Chemical equivalent of the same, in the presence of an Inert disolventeorganico to reaccion.de application in t Treatment of stomach ulcers.