SUBSTITUTED PHENYL DERIVATIVE, ITS PREPARATION, AND REMEDY CONTAINING IT

摘要

NEW MATERIAL:A compound shown by the formula I [R1 is H, alkyl, alkoxy, alkenyl, etc.; R2 is H, or CH3; R3 is hydroxymethyl, carboxyl, carboxymethyl, etc.; R4 is H, halogen, or alkyl; X is CH2O, CH2S, CH2NH, CH2NR5 (R5 is alkyl, or phenyl), CONR5, etc.; n is 0-2; bond containing dotted line is double bond, or single bond], its salt, or its acid addition salt. EXAMPLE:O-(P-Amylcinnamyl) salicylic acid. USE:A leulotriene antagonist, phospholipase inhibitor, and 5alpha-reductase inhibitor. PREPARATION:For example, a compound shown by the formula II is reacted with a (thiol)phenol derivative or aniline derivative shown by the formula III (Y is O, S, or NR6; R6 is H or R5) in an inert organic solvent at room temperature -80 deg.C, to give a compound shown by the formula I where X is CH2O, CH2S, CH2NG, or CH2NR5.