DIAZ(EP)INBIS(N-AMIDINOAMIDINE) DERIVATIVE, MANUFACTURE AND ANTIBACTERIAL OR ANTIFUNGAL COMPOSITION

摘要

A diaz(ep)ine bis(N-amidinoamidine) derivative of the formula:- CHEM or a tautomeric form thereof, wherein R10, R11, R12, R13, R14, R15, R16 and R17, which may be the same or different, are each hydrogen, a 1-16C alkyl radical, a 3-18C cycloalkyl or cycloalkylalkyl radical, or an optionally-substituted phenyl (1-4C alkyl) radical, or R10, R11 and the nitrogen atom to which they are attached, or R12 and R13 and the nitrogen atom to which they are attached, or R14 and R15 and the nitrogen atom to which they are attached, or R16 and R17, and the nitrogen atom to which they are attached, which may be the same or different, are each a 1-azetidinyl, 1-pyrrolidinyl, piperidino, hexamethyleneimino, heptamethyleneimino, morpholino or 4-(1-8C alkanoyl)-1-piperazinyl radical, or R10 and R14 together with the two nitrogen atoms to which they are attached and the intervening carbon atom, or R12 and R16 together with the two nitrogen atoms to which they are attached and the intervening carbon atom, each forms a 1,3-diazaheterocyclic radical of 5 to 7 atoms, which heterocyclic radicals may be the same or different; and m is 2 or 3; provided that R10, R11, R12, R13, R14, R15, R16 and R17 together contain 16 to 28 carbon atoms, and the acid addition salts thereof, processes for their manufacture and antibacterial and antifungal compositions and methods using said compounds.