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maenniskans monoklonala antikroppar mot serotypiska lipopolysackariddeterminanter av gram negativa bakterier samt deras framstaellning.
maenniskans monoklonala antikroppar mot serotypiska lipopolysackariddeterminanter av gram negativa bakterier samt deras framstaellning.
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机译:人革兰氏阴性细菌血清型脂多糖决定簇的人单克隆抗体及其生产。
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摘要
Transformed human lymphocyte cell lines have been produced which secrete human monoclonal antibodies to serotypic determinants on LPS molecules of gram-negative bacteria. These antibodies have been found to be protective against lethal challenges of the homologous bacteria. Pharmaceutical compositions containing these antibodies and their prophylactic and therapeutic use in the management of gram-negative disease in humans are also disclosed. Human lymphocyte cell lines secreting human monoclonal antibodies specifically reacting with Pseudomonas aeruginosa Fisher immunotypes 1 (C5B7), 2 (6F11), 4 (C5D5), 5 (13C1), 6 (5G2) and 7 (8E7) were deposited at the American Type Culture Collection and given A.T.C.C. Accession Nos. CRL 8753, CRL 8562, CRL 8754, CRL 8796, CRL 8797 and CRL 8795, respectively.
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