PROCESS FOR OBTAINING CRYSTALLINE, NON-HYDROSCOPIC, WATER-SOLUBLE ETHYLENEDIAMINE, MONOETHANOLAMINE AND DIETHANOLAMINE SALTS OF N-(2-PYRIDYL)-2-METHYL-4-HYDROXY-2H-1,2-BENZOTHIAZEPINE-3-CARBOXAMIDE 1,1-DIOXIDE

摘要

The water-soluble ethylenediamine, monoethanolamine and diethanolamine salts of N-(2-pyridyl)-2-methyl-4-hydroxy-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide have been prepared. These novel crystalline salts are useful in therapy as non-steroidal anti-arthritic agents. Methods for preparing these salts from the corresponding acidic starting material and the appropriate amine base are provided.