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2.4 - diclorofenti - imidazolil - etanoni (oils), process for their preparation and their use as medicinal products

机译:2.4-双氯杀螨醇-咪唑洛利-依塔尼尼(油),其制备方法及其用作药物的用途

摘要

2,4-Dichlorophenylimidazolyl ethanones or ethanols of the general formula IMAGE in which A represents a keto group or a CH(OH) group, X represents halogen, alkyl, or optionally substituted phenyl, and n represents zero or an integer from 1 to 3, and their physiologically tolerated salts, are therapeutically active and are obtained by reacting a compound of the formula II with imidazole. Surprisingly, the active compounds according to the invention demonstrate better antimycotic, therapeutically useful, activity than do the phenoxyimidazolyl derivatives known from the state of the art, which derivatives are the most closely related compounds from the point of view of their chemistry and the nature of their effect. IMAGE
机译:通式的2,4-二氯苯基咪唑基乙酮或乙醇,其中A表示酮基或CH(OH)基,X表示卤素,烷基或任选取代的苯基,n表示0或1的整数式1-3的化合物及其生理耐受盐具有治疗活性,并且是通过使式II的化合物与咪唑反应而获得的。令人惊讶地,与现有技术中已知的苯氧基咪唑基衍生物相比,根据本发明的活性化合物表现出更好的抗真菌的,治疗上有用的活性,从它们的化学性质和性质来看,这些衍生物是最紧密相关的化合物。他们的效果。 <图像>

著录项

  • 公开/公告号IT1093702B

    专利类型

  • 公开/公告日1985-07-26

    原文格式PDF

  • 申请/专利权人 BAYER AG;

    申请/专利号IT19780020129

  • 发明设计人

    申请日1978-02-09

  • 分类号A61K;

  • 国家 IT

  • 入库时间 2022-08-22 08:09:29

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