SOLUBLE N.SUB.2 SUBSTITUTED DERIVATIVES OF 2,4- DIAMINO-5-BENZYL-PYRIMIDINE, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM

摘要

Novel soluble N2 substituted derivatives of 2,4-diamino-5-benzyl pyrimidines as well as processes for their production are provided herein. These derivatives correspond to the general formula III below: (III) IMG in which R1, R2, R3, R4 which may be identical or different, represent a hydrogen atom, a halogen atom or an alkyl, thioakyl, alkoxy, benzyloxy-, or alkyloxyalkoxy group; Y represents a hydrogen atom, an alkali metal or a pharmaceutically compatible organic base, and R represents a hydrogen atom or a linear or branched alkyl radical containing from 1 to 7 carbon atoms, a cycloalkyl radical containing from 5 to 8 carbon atoms, phenyl, a methylene dioxy ring or an ethylene dioxy ring, or a 5- or 6-membered heterocyclic ring, in which the heterocyclic atom is N, S or O, e.g. furane, thiophene, or pyridine. Such novel soluble N2 substituted derivatives are powerful anti-bacterial agents.