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Method and reagent for making a radiopharmaceutical composition based on technetium - 99m
Method and reagent for making a radiopharmaceutical composition based on technetium - 99m
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机译:基于tech的放射性药物组合物的制备方法和试剂-99m
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摘要
A method of making a radiopharmaceutical composition by mixing an aqueous solution of pertechnetate with a reducing agent comprising tin metal or stannous ion to reduce the pertechnetate and a complexing agent to form a complex with the reduced technetium, is characterized by incorporating nitrate and or nitrite in an amount to diminish oxidation of Sn2- to Sn4-, and hence to prevent re-oxidation of technetium to pertechnetate, during preparation and storage of the complex. Nitrate and nitrite are superior to organic antioxidants previously proposed.;A reagent for the purpose comprises the reducing agent, the complexing agent and tne nitrate and,or nitrite usually in a sterile freeze-dried state.
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