A Comparative Study on the Labelling of Radiopharmaceutical Kits with ~(99m)Tc Obtained from F.P. ~(99)Mo/~(99m)Tc Generator and PZC- Based ~(99)Mo/~(99m)Tc Generator

摘要

A Comparative Study on the Labelling of Radiopharmaceutical Kits with ~(99m)Tc Obtained from F.P. ~(99)Mo/~(99m)Tc Generator and PZC-Based ~(99)Mo/~(99m)Tc Generator. Labelling comparison of radiopharmaceutical kit with ~(99m)Tc obtained from different generator may assist in the evaluation of a generator quality. Technetium-99m from ~(99)Mo/~(99m)Tc Generator based on fission product is commonly used in nuclear medicine all over the world. A ~(99)Mo/~(99m)Tc generator was prepared by reacting high activity ~(99)Mo (+- 300 mCi) of neutron natural molybdenum with PZC materials. The generator resulted in high ~(99m)Tc yields and low ~(99)Mo breakthrough in the presence of a low concentration oxidizing agent (NaOCl~-").Technetium-99m obtained from both generators were labelled to pyrophosphate, HMPAO and MIBI kits, respectively. The chemical and biological properties of ~(99m)Tc obtained from both generators afford the similar radiochemical purity and biodistribution pattern.