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METHOD AND REAGENT FOR MAKING A RADIOPHARMACEUTICAL COMPOSITION BASED ON TECHNETIUM - 99M
METHOD AND REAGENT FOR MAKING A RADIOPHARMACEUTICAL COMPOSITION BASED ON TECHNETIUM - 99M
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机译:基于--99M的放射性药物组成的方法和试剂。
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摘要
A method of making a radiopharmaceutical composition by mixing an aqueous solution of pertechnetate with a reducing agent comprising tin metal or stannous ion to reduce the pertechnetate and a complexing agent to form a complex with the reduced technetium, is characterized by incorporating nitrate and/or nitrite in an amount to diminish oxidation of Sn2+to Sn4+, and hence to prevent re-oxidation of technetium to pertechnetate, during preparation and storage of the complex. Nitrate and nitrite are superior to organic antioxidants previously proposed. A reagent for the purpose comprises the reducing agent, the complexing agent and the nitrate and/or nitrite usually in a sterile freeze-dried state.
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