DRUG, CONTAINING PROSTAGLANDIN I2 ANALOG COMPOUND, AND HAVING AMELIORANT ACTION ON CIRCULATION AND ANTIULCER ACTION

摘要

PURPOSE:The titled drug containing a prostaglandin I2 analog compound. CONSTITUTION:A drug containing a compound expressed by formula I (R1 is H, 1-12C alkyl, 4-7C cycloalkyl, etc.; A is pentyl, cyclopentyl, etc.) or a nontoxic salt of the acid or a cyclodextrin clathrate compound thereof as an active constituent, and having ameliorant action on circulation and antiulcer action. The agent has powerful inhibitory action on blood platelet agglutination, hypotensive action, vasodilator action and antiulcer action, and low toxicity. The agent can be orally or parenterally administered, and the dose thereof is 0.1- 100mg/time, preferably 1mug-1mg/time, and preferably administered one - several times a day. The compound expressed by formula I is obtained by reducing a compound expressed by formula II (R1' is 1-2C alkyl, 4-7C cycloalkyl, etc.; R2 is a protecting group of OH), removing the protecting group from the reduction product and hydrolyzing the resultant product, etc.