Aqueous crystalline suspensions of glycolic-acid esters of steroids

摘要

An aqueous crystal suspension of a 17-tertiary steroid glycoester is described, characterized in that it contains a compound of the general formula I IMAGE in which X is two hydrogen atoms or one oxygen atom, Y two hydrogen atoms or a methylene group, R 1 is a hydrogen atom or a methyl group, Z is a Hydroxy group or the group - O - CO - R² with R² meaning a methyl or phenyl group, and IMAGE mean a C - C single or double bond, contains in the following fractions: 0-30 percent by weight of particle size 3-15 µm, 40-90 percent by weight of particle size 15-60 µm, and 20-60 percent by weight of particle size 30-100 µm. After a single intramuscular injection of 30-75 mg steroid glycoester as an aqueous crystal suspension, a sufficiently high, evenly running steroid spatula is detected in the plasma over 4 weeks.