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Process for the production of N-(2-methyl-4-chlorophenyl)- formamidine derivatives

机译:N-(2-甲基-4-氯苯基)-甲am衍生物的生产方法

摘要

A process for the production of N-(2-methyl-4-chlorophenyl)- formamidine derivatives of formula ##STR1## wherein R.sub.1 is hydrogen or an alkyl radical having 1 to 4 carbon atoms and R.sub.2 is an alkyl radical having 1 to 4 carbon atoms is disclosed which comprises reacting an N-substituted formamide with an inorganic acid chloride, such as phosphorus oxychloride, thionylchloride and phosgene, condensing the intermediate formed with o-toluidine and subsequently chlorinating the N- (2-methylphenyl)-formamidine derivative formed, all reaction steps involved in said process being carried out in the same solvent which is selected from the group of halogenated hydrocarbons.
机译:制备式## STR1 ##的N-(2-甲基-4-氯苯基)-甲am衍生物的方法,其中R1是氢或具有1-4个碳原子的烷基。图2是公开的具有1至4个碳原子的烷基,其包括使N-取代的甲酰胺与无机酰氯,例如三氯氧磷,亚硫酰氯和光气反应,使形成的中间体与邻甲苯胺缩合,然后将N-氯化。形成(2-甲基苯基)-甲am衍生物,所述方法中涉及的所有反应步骤均在选自卤代烃的同一溶剂中进行。

著录项

  • 公开/公告号US4612395A

    专利类型

  • 公开/公告日1986-09-16

    原文格式PDF

  • 申请/专利权人 CIBA-GEIGY CORPORATION;

    申请/专利号US19780932830

  • 发明设计人 RAOUL NEBEL;ROLAND DOUSSE;

    申请日1978-08-11

  • 分类号C07C123/00;

  • 国家 US

  • 入库时间 2022-08-22 07:28:45

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