Method for preparing a Solid dispersion of a pharmacologically Active dishidropiridina in a Crystalline Matrix as a vehicle.

摘要

Method for preparing a Solid dispersion of a dihydropyridine drugs.Comprising: (a) Dissolving Active dihydropyridine with a concentration of 80% by weight, in a Matrix of Liquefied polialquilen glycol, at a temperature between 50 and 85jc; (b) to transform the dispersion in solid form; (c) the solid form in form of granular grains; and (d) to crystallize the dihydropyridine Active in the grain, to obtain a uniform structure.Dihydropyridine choose between acid ethyl ester (4 - Silence - RAW - 4-yl) - 1,4 - dihydro - 4 - ethoxy - carbocil 2,6-dimethyl pyridine carboxylic acid and Ester - 3 - 4 - isopropyl acid (Silence - RAW - 4-yl) - 1,4 - dihydro - 4 - metoxicarbocil - 2.6 - dimethyl - 3 - pyridine carboxylic acid. It is used to treat angina.