5,6,7-TRINOR-4,8-INTER-M-PHENYLENE PROSTAGLANDIN I.SUB.2 DERIVATIVE

摘要

TITLE OF THE INVENTION:5,6,7-TRINOR-4,8-INTER-m-PHENYLENEPROSTAGLANDIN I2 DERIVATIVEABSTRACT OF THE DISCLOSURE:A compound of the formula (I)wherein R1 is a pharmaceutically acceptable cation, hydrogen orn-alkyl of 1 to 12 carbon atoms; R2 is hydrogen, acyl of 2 to 10carbon atoms or aroyl of 7 to 13 carbon atoms; R3 is hydrogen,acyl of 2 to 10 carbon atoms or aroyl of 7 to 13 carbon atoms;R4 is hydrogen, methyl or ethyl; R5 is n-alkyl of 1 to 5 carbonatoms; n is an integer of 0 to 4; A is -CH2-CH2- or trans-CH=CH-; and X is -CH2-CH2- or trans -CH=CH-.