首页> 外国专利> 1-3-(2-Hydroxy-3-alkylamino-propoxy)-2-thienyl-3-phenyl-1-propanones and their acid addition salts, process for their preparation and pharmaceutical compositions containing them

1-3-(2-Hydroxy-3-alkylamino-propoxy)-2-thienyl-3-phenyl-1-propanones and their acid addition salts, process for their preparation and pharmaceutical compositions containing them

机译:1- [3-(2-羟基-3-烷基氨基-丙氧基)-2-噻吩基] -3-苯基-1-丙烷及其酸加成盐,其制备方法和含有它们的药物组合物

摘要

1-[3-(2-Hydroxy-3-alkylaminopropoxy)-2-thienyl]-3-phenyl-1-propa- nones of the formula IMAGE in which R and R1 in each case denote hydrogen or methyl, but at least one of these denoting methyl, R2 denotes alkyl, cycloalkyl or alkenyl each having up to 8 C atoms and R3 represents hydrogen or R2 and R3, together with the nitrogen atom bonding them, form a 6-membered saturated heterocyclic ring, which can optionally be substituted by an alkyl radical having 1 to 3 C atoms, with the proviso that R2 has a meaning other than propyl, n-butyl, isobutyl or tert-butyl if R3 is hydrogen, and their acid addition salts can be used for the treatment of cardiac arrhythmias.
机译:式<图像>的1- [3-(2-羟基-3-烷基氨基丙氧基)-2-噻吩基] -3-苯基-1-丙烷基,其中R和R1分别表示氢或甲基,但在这些中的至少一个表示甲基,R 2表示各自具有至多8个碳原子的烷基,环烷基或烯基,并且R 3表示氢或R 2和R 3与结合它们的氮原子一起形成6元饱和杂环,其可以任选地可以被具有1-3个碳原子的烷基取代,条件是如果R3是氢,则R2具有除丙基,正丁基,异丁基或叔丁基以外的含义,并且它们的酸加成盐可以用于处理心律失常。

著录项

  • 公开/公告号EP0233173A1

    专利类型

  • 公开/公告日1987-08-19

    原文格式PDF

  • 申请/专利权人 LAEVOSAN-GESELLSCHAFT M.B.H.;

    申请/专利号EP19870890016

  • 发明设计人 BINDER DIETER DR.;FERBER HUBERT DR.;

    申请日1987-01-28

  • 分类号C07D333/32;A61K31/38;

  • 国家 EP

  • 入库时间 2022-08-22 07:14:51

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