METHOD FOR PRODUCING ACID-ADDITIVE SALTS OF 3,4-DIISOBUTYRYLOXY-N-N-METHYLPHENETHYLAMINE

摘要

The invention provides novel compounds of formula …CHEM… in which R is isobutyryloxy and salts thereof, processes for making it and a new process for the preparation of therapeutically active 3,4-di-isobutyryloxy-N-methyl- phenethylamine (I) …CHEM… and its acid addition salts. According to the process 3,4-dimethoxyphenethylamine is reacted with benzaldehyde and formaldehyde in the presence of hydrogen and a catalyst to give a compound of formula (II) …CHEM… The compound (II) is demethylated to give …CHEM… and then reacted with isobutyryl chloride in the presence of a base to give a compound of formula IV …CHEM… from which the benzyl protecting group is removed by catalytical hydrogenation whereby compound (I) is obtained.