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METHOD OF PRODUCING DIAZINE-CONTAINING DERIVATIVES OF OXAMIC ACID OR SALTS THEREOF WITH PRIMARY OR SECONDARY AMINES OR ALKALI METALS OR ACID-ADDITIVE SALTS WITH MINERAL ACIDS
METHOD OF PRODUCING DIAZINE-CONTAINING DERIVATIVES OF OXAMIC ACID OR SALTS THEREOF WITH PRIMARY OR SECONDARY AMINES OR ALKALI METALS OR ACID-ADDITIVE SALTS WITH MINERAL ACIDS
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机译:用初级或二级胺或碱金属或含矿物质酸的食盐生产含二嗪或乙二醛的衍生物的方法
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摘要
Compounds of the formula CHEM wherein R1 is hydrogen or alkyl of 1 to 4 carbon atoms; R2 is hydrogen, methyl, hydroxyl, alkoxy of 1 to 4 carbon atoms, di(alkyl of 1 to 2 carbon atoms)amino-(alkoxy of 1 to 4 carbon atoms) or -HN-CO-CO-OR1; A is CHEM R3 is hydrogen, methyl, alkoxy of 1 to 4 carbon atoms, hydroxyl, amino, alkanoyloxy of 1 to 2 carbon atoms, di(alkyl of 1 to 2 carbon atoms)amino-(alkoxy of 1 to 4 carbon atoms) or acetamido; and R4 is hydrogen, amino, alkoxy of 1 to 4 carbon atoms, halogen or -HN-CO-CO-OR1; and, when R1 is hydrogen, non-toxic, pharmacologically acceptable salts thereof. The compounds as well as their salts are useful for the treatment of immunological, inflammatory and allergic disorders such as allergic asthma, rhinitis, conjunctivitis, hay fever, urticaria, food allergies and the like.
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