3,4-dihydro-1,3-disubstituted-6-(substituted phenylimino)-2(1H)- pyrimidinone useful as cardiotonic agent and anti-allergic agent

摘要

The invention relates to novel pyrimidinone compounds of anti- allergic and cardiotonic activity of the formula: ##STR1## wherein R.sup. 1 and R. sup.2 are each lower alkyl, lower alkoxycarbonyl(lower)alkyl, carboxy(lower)alkyl or di(lower)alkylamino(lower)alkyl,PP R.sup.3 is hydroxy, lower alkoxy, halo(lower)alkoxy, lower alkylthio, lower alkanesulfinyl, lower alkanesulfonyl, nitro, amino or di(lower) alkanesulfonylamino,PPR.sup.4 is hydroxy, lower alkoxy, halo(lower)alkoxy, lower alkoxycarbonyl(lower)alkoxy or carboxy(lower) alkoxy, orPPR.sup.3 and R.sup.4 are taken together to form lower alkylenedioxy or lower alkylidenedioxy,PPR.sup. 5 is phenyl substituted with 1 to 4 substituents selected from the group consisting of lower alkyl and sulfamyl,PPR.sup.10 is hydrogen or sulfamyl, provided that when both of R.sup.1 and R.sup.2 are lower alkyl and R.sup.3 and R.sup.4 are lower alkoxy, then R.sup.10 is sulfamoyl, and that when R.sup.3 is hydroxy, then R.sup.4 is hydroxy, and pharmaceutically acceptable salts thereof.