Compounds of the formula IMAGE I wherein R1 is hydrogen or a conventional amino-protecting group, R2 and R3 each are independently methyl or ethyl, and R4 is methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, allyl, 2-butenyl, 3-butenyl, 2-hydoxyethyl, 3-hydroxypropyl, 2-(dimethylamino)ethyl, pyridylmethyl, pyridylethyl, benzyl or phenethyl, and nontoxic pharmaceutically acceptable acid addition salts and solvates thereof, as well as processes for their preparation, are disclosed. The compounds in which R1 is hydrogen are potent antibacterial agents.
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机译：式 I的化合物，其中R 1是氢或常规的氨基保护基，R 2和R 3各自独立地是甲基或乙基，并且R 4是甲基，乙基，正丙基，异丙基，正丁基，异丁基，烯丙基，2-丁烯基，3-丁烯基，2-羟乙基，3-羟丙基，2-（二甲基氨基）乙基，吡啶基甲基，吡啶基乙基，苄基或苯乙基，及其无毒的药学上可接受的酸加成盐和溶剂化物，及其制备方法公开。 R 1为氢的化合物是有效的抗菌剂。
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