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PROCESS FOR MAKING CONTROLLED PHARMACEUTIC FORMULATIONS OF LONG TIME EFFECT IN SHAPE OF DOSE UNIT HAVING SINGLE BIOACCESNESS CHARACTERISTICS
PROCESS FOR MAKING CONTROLLED PHARMACEUTIC FORMULATIONS OF LONG TIME EFFECT IN SHAPE OF DOSE UNIT HAVING SINGLE BIOACCESNESS CHARACTERISTICS
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机译:具有单一生物利用度特征的剂量单位形状中长时间作用的受控药物制剂的制备方法
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摘要
A method of preparing a multiplicity of controlled, long-acting release pharmaceutical tablets, each containing a therapeutic agent and a cellulosic ether carrier base material is shown. The method includes the steps of adding a quantity of cellulose ether base material such as hydroxypropyl methylcellulose and an active therapeutic agent to form a mixture, thoroughly and uniformly mixing that mixture, discontinuing the mixing, permitting the uniform mixture to stand for a period of time, typically two to twenty-four hours or longer, sufficient to cause the therapeutic agent to become bonded to the carrier base material and compressing portions of the mixture to form the solid unit dose tablets. The advantage of the method is that the time release of each tablet from a given batch of formulation and the time release characteristics of tablets prepared in different batches, will be substantially more uniform and comparable.
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