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Method for preparing a complex Therapeutic of plasminogen activator and poly (Ester of sulfuric acid) of sulfated saccharide or Sugar.
Method for preparing a complex Therapeutic of plasminogen activator and poly (Ester of sulfuric acid) of sulfated saccharide or Sugar.
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机译:纤溶酶原激活剂与硫酸化糖或糖的聚(硫酸酯)复合疗法的制备方法。
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摘要
Procedure for preparing a Therapeutic Compound. Comprising: (a) mixing a Plasminogen Activator (PA) with a Poly (Ester of sulfuric acid) of a Sugar (Saccharide or sulfated heparin), in an aqueous solution of pH between 4 and 10 in a molar ratio of 1: sulfated Sugar plasminogen / 100.000, and between 4 and 25jc; (b) Incubating the mixture for 24 hours; (c) the mixture incubated dialyzed to remove excess Poly (Ester of sulfuric acid) a saccharide, to form a complex Mix; (d) The complex with a Stabilizer; and e) freeze-drying set.Plasminogen activator tissue plasminogen is chosen or its derivatives present in nature and the Stabilizer choose between Albumin or gelatin. Used for the treatment of Thrombosis and embolisms.
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