Preparing optically active 4-(ammonium ethyl)benzoic acid methyl ester-sulfate comprises reacting a racemic mixture of 4-(1-aminoethyl)-benzoic acid methyl ester with acylating agent and lipase, and adding sulfuric acid

摘要

Production of optically active 4-(ammonium ethyl) benzoic acid methyl ester-sulfate (I) comprises reacting a racemic mixture of 4-(1-aminoethyl)-benzoic acid methyl ester with an acylating agent in the presence of lipase to give 4-(aminoethyl) benzoic acid methyl ester and subsequently precipitating 4-(ammonium ethyl)benzoic acid methyl ester-sulfate by adding sulfuric acid. Independent claims are included for: (1) (S)-4-(ammonium ethyl) benzoic acid methyl ester sulfate; and (2) (R)-4-(ammonium ethyl) benzoic acid methyl ester sulfate.