5 - Hydroxycaproic - pgf (arrow down) 1 (arrow down) (arrow down) (alpha) (arrow down) - 1,5 - lactone - derivatives, processes for their preparation and pharmaceutical preparations, various containing these compounds

摘要

The invention relates to compounds: IMAGE wherein R1 stands for hydrogen or an R2-CO-,trialkylsilyl, alkoxyalkyl or tetrahydropyranyl group; R2 represents a straight or branched chain C1-4 alkyl, phenyl or substituted phenyl group; A means hydrogen; B means hydrogen, iodine, bromine or a C6H5-Se-group; C stands for hydrogen; or A and B together may represent a chemical bond and C is hydrogen; or B and C together may represent a chemical bond and A is hydrogen; D means hydrogen or an R3O- group with alpha- or beta-configuration; E stands for hydrogen, -CH2-O-R4 group with alpha- or beta-configuration or -F-(CHOR4)-R5 with @@@ alpha- or beta- configuration; D and E together form a chemical bond; R3 means hydrogen or an R2-CO-, trialkylsilyl, alkoxyalkyl or tetrahydropyranyl group; R4 is hydrogen or an R2-CO-, trialkylsilyl, alkoxyalkyl or tetrahydropyranyl group; F stands for a -C IDENTICAL C-, cis or trans -CH=CH- group; and R5 means a straight or branched chain C4-8 alkyl or a C5-6 cycloalkyl group. The compounds of the formula (I) are useful intermediates for the preparation of further products of formula (I); they also show a biological action (platelet aggregation-inhibiting effect) similar to though weaker than that of prostacyclin and have a higher stability.