(Delta) (arrow high) 8 (arrow high) - and (delta) (arrow high) 9 (arrow high) - prostaglandin - derivatives, processes for their preparation and their pharmaceutical use

摘要

DELTA 8- and DELTA 9-prostaglandine derivates are disclosed, having the formula (I), in which (a) represents the residues (b) or (c); R1 represents the groups (d), (e), COOR4 or CONHR5; R2 and R3 represent each a hydrogen atom or a hydroxyl group, whereas the OH group may be in the alpha - or beta -position; X is a CH2-group, an O or S atom; W is hydrogen, -OR6, halogen, -CN-, -NO2, trifluoromethyl or COOR6, and when R4 is hydrogen, their salts with physiologically tolerable bases. alpha -, beta - or gamma -cyclodextrinclathrates are also disclosed, as well as liposome-encapsulated compounds having the formula (I), their process of production and their pharmaceutical use.