Radioactively with (arrow high) 1 (arrow high) (arrow high) 2 (arrow high) (arrow high) 5 (arrow high) i - marked 1,4 - dihydropyridines of pyridine derivatives and 1,4 - dihydropyridines of quinoline derivatives, their preparation and their use for testing of medicaments

摘要

a simple method for the production of highly radioactive, with 125i labelled, 1,4 - dihydropyridine and 1.4 dihydrochinolinderivaten allows specific radioactivity: approximately 2200 - 8800 ci / mmol to achieve.this high sensitivity of the arzneimittelscreening with the help of the radiorezeptorassays, for the determination of plasma levels of 1,4 - dihydropyridine, 1.4 - dihydrochinolinen and other substances, the receptors for 1.4 and 1.4 - dihydropyridines, dihydrochinoline interact,so that a much shorter exposure duration in the autoradiographischen presentation of the receptors for these substances is achieved.this is a aminoderivat a 1.4 - dihydropyridins or 1.4 dihydrochinolins with a acylierenden reagent which with 125i radioactive (2200 - 4400 ci / mmol) is selected, implemented and the 125i - substituted 1,4 - dihydropyridine or 1.4 dihydrochinolinderivat, what the specific radioactive if the acylierenden reagent has always known separation techniques in isolation.