Production of lymphoid tissue effector cells reactive against cancer cells by means of MER, and use thereof in cancer therapy

摘要

The addition of small amounts of MER to an in vitro culture of animal or human lymphocytes together with cancer cells will greatly potentiate the process by which the lymphocytes become actively cytotoxic to the specific type of cancer cells when injected in vivo. In some cases MER causes sensitization of the lymphocytes even when there is none without the MER. MER cultured in vitro with lymphocytes without specific cancer cells in the culture will cause non-specific cytotoxic sensitization of the lymphocytes. The sensitized cytotoxic reactive cells may be stored cryogenically for use in human cancer therapy.