PRODUCTION OF AROMATIC HYDROXIDE DERIVATIVE BY REACTION OF BAEYER-VILLIGER REACTION

摘要

PURPOSE: To prepare the compound advantageously by the production where acetic anhydride is added to H₂O₂ solution in dichloroethane in the presence of strong acidic catalyst to obtain peracetic acid and then adding aromatic aldehyde and/or arylketone, and by reacting the mixture at a low temperature. ;CONSTITUTION: As a first step, acetic anhydride is added to hydrogen peroxide solution in dichloroethane in the presence of strongly acidic catalyst such as sulfuric acid phosphoric acid, certain types of positive-ion exchange resins or the like to obtain peracetic acid. As a second step, aromatic aldehyde or arylketone is added to the above solution, allowed to react therewith at the temperature of the medium of 40°C or less. That is, aromatic hydroxide derivatives are obtained by the Beayer-Villinger reaction. As the aromatic aldehyde or arylketone, the compounds of formula (Ar is monocyclic, multi-cyclic or heterocyclic; R¹ is alkyl, alkoxy, phenyl or the like; n is 1 or 2; R is H, alkyl or the like) is preferable. The production can be carried out safely under a gentle condition.;COPYRIGHT: (C)1989,JPO