method of therapeutically useful aromaattisesti substituted alkyyliaminoalkaanidifosfonihappojen preparation

摘要

Araliphatylaminoalkanediphosphonic acids of the formula IMAGE in which R1 represents an aromatically substituted aliphatic radical, R2 represents hydrogen or a monovalent aliphatic radical and alk denotes a divalent aliphatic radical, and their salts have a marked regulating action on calcium metabolism and can be used as medicaments for the treatment of diseases which can be traced back to disorders thereof. They are prepared, for example, by reacting a compound of the formula IMAGE in which X3 denotes carboxyl and R0 denotes a radical R2, with phosphorous acid and phosphorus trichloride and hydrolysing the primary product.