A process for the preparation of novel proteins derived from the inhibitor of human alpha2-PLASMINE or similar proteins, from a DNA encoding for these proteins, from plasmids containing said DNA and from cells transformed with said plasmids

摘要

An alpha 2-plasmin inhibitor ( alpha 2-PI) derivative which has essentially the amino acid sequence of alpha 2-PI but for the reactive site cleavable with plasmin, which reactive site is either deleted or replaced by the reactive site of an antithrombin active serine protease inhibitor cleavable with thrombin, prevents blood coagulation and is useful in the therapy of cardiovascular disturbances or diseases.