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TISSUE PLASMINOGEN ACTIVATOR ACTIVITY MEASUREMENT USING ANTIBODY WITH AFFINITY TO SITE OTHER THAN ACTIVE SITE OF TPA
TISSUE PLASMINOGEN ACTIVATOR ACTIVITY MEASUREMENT USING ANTIBODY WITH AFFINITY TO SITE OTHER THAN ACTIVE SITE OF TPA
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机译:利用能够在除TPA活性部位以外的部位亲和力的抗体测定组织中的纤溶酶原活化剂活性
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摘要
True activity of tissue plasminogen activator is determined by reacting a solid phase having bound thereto anti tissue plasminogen activator antibody IgG fragment having affinity to a site other than the active site of tissue plasminogen activator with tissue plasminogen activator in a sample and then measuring activity of the reaction product, preferably in terms of amount of substance released from a chromogenic peptide substrate. This measurement enables use of whole blood or diluted blood as the sample and achieves high sensitivity and high accuracy in a short period of time.
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