MONOCLONAL ANTIBODY AGAINST BONE ALKALINE PHOSPHATASE

摘要

Monoclonal antibody (mAb) 1E10.1 immunologically distinguishing human bone from human liver alkaline phosphatase isoenzymes by specific binding to the former and not the latter is developed. mAb 1B12 is useful as a positive control as it reacts with human bone and liver ALP. Also developed is mAb 2B11 (2B11.1) which is useful as a positive control in rat ALP systems as it reacts with rat bone, liver, kidney and cartilage ALP.