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Monoclonal antibody against bone alkaline phosphatase
Monoclonal antibody against bone alkaline phosphatase
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机译:骨碱性磷酸酶单克隆抗体
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摘要
Monoclonal antibody (mAb) 1E10.1 immunologically distinguishing human bone from human liver alkaline phosphatase isoenzymes by specific binding to the former and not the latter is developed. mAb 1B12 is useful as a positive control as it reacts with human bone and liver ALP. Also developed is mAb 2B11 (2B11.1) which is useful as a positive control in rat ALP systems as it reacts with rat bone, liver, kidney and cartilage ALP.
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机译:通过与前者而非后者的特异性结合,开发了从人体免疫学上将人骨与人肝碱性磷酸酶同工酶区分开的单克隆抗体(mAb)1E10.1。 mAb 1B12与人的骨骼和肝脏ALP反应,因此可用作阳性对照。还开发了mAb 2B11(2B11.1),可在大鼠ALP系统中用作阳性对照,因为它与大鼠骨骼,肝脏,肾脏和软骨ALP反应。
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