Combination of pyrimidine derivatives and fluorized steroidal anti-inflammatory agents to induce and stimulate the hair growth and to reduce hair loss

摘要

Combination intended for inducing and stimulating hair growth and reducing hair loss, which comprises: a/ a component (A) containing, in a physiologically acceptable medium, at least one fluorinated steroidal anti-inflammatory agent, and b/ a component (B) containing, in a physiologically acceptable medium, at last one pyrimidine derivative corresponding to the formula: IMAGE in which R1 denotes a group IMAGE in which R3 and R4 independently of one another, denote hydrogen or an alkyl, alkenyl, alkylaryl or cycloalkyl group, R3 and R4 with the nitrogen atom to which they are linked can also form a heterocycle chosen from aziridinyl, azetidinyl, pyrrolidinyl, piperidyl, hexahydroazepinyl, heptamethylenimine, octamethylenimine, morpholine and 4-[(lower)alkyl]piperazinyl groups, it being possible for the heterocyclic groups to be substituted on the carbon atoms with one to three lower alkyl, hydroxyl or alkoxy groups; the group R2 is chosen from a hydrogen atom and an alkyl, alkenyl, alkylalkoxy, cycloalkyl, aryl, alkylaryl, arylalkyl, alkylarylalkyl, alkoxyarylalkyl or haloarylalkyl group; as well as the addition salts with physiologically acceptable acids, the components (A) and (B) forming part of one and the same composition or being intended for use separately, either simultaneously or successively or separated by an interval of time, on the scalp or the hair.