New derivatives of indane, their process of preparation and the new # thus obtained, their application as medicinal products and the compositions containing them,

摘要

A compound selected from the group consisting of all enantiomeric and diastereoisomeric forms possible of compounds of the formula IMAGE I wherein X is selected from the group consisting of hydrogen, halogen, and alkyl and alkoxy of 1 to 5 carbon atoms, R1 and R2 are individually selected from the group consisting of hydrogen and alkyl of 1 to 5 carbon atoms, one of A and B being IMAGE and the other being IMAGE R is hydrogen or alkyl of 1 to 5 carbon atoms, Z is -(CH2)n- or branched alkylene of 2 to 8 carbon atoms, n is an integer from 0 to 5, Y is selected from the group consisting of naphthyl, indenyl, heterobicyclics and heteromonocyclic containing 5 to 6 ring members, all optionally substituted with at least one member of the group consisting of alkyl and alkoxy of 1 to 5 carbon atoms, halogen, -OH, -CF3, -NO2, -NH2, monoalkylamino and dialkylamino of 1 to 4 alkyl carbon atoms and phenyl optionally substituted with at least one member of the group consisting of halogen and alkyl and alkoxy of 1 to 4 carbon atoms, R3 and R4 are individually hydrogen or alkyl of 1 to 5 carbon atoms or taken together with the nitrogen form a heterocyclic of 5 to 6 ring members and optionally containing -O-, -S- or nitrogen in the ring and their non-toxic, pharmaceutically acceptable acid addition salts having central analgesic and antiarythmic activity among other activities.