9-(SUBSTITUTED THIO)-4H-PYRIDO1,2-APYRIMIDIN-4-ONE DERIVATIVES, THEIR MANUFACTURE AND USE

摘要

9-(Substituted thio)-4H-pyrido[1,2-a]pyrimidin-4-one derivatives of the formula: IMAGE (I) wherein n is 0 or 1, R is -COR1, -CONR4R5 or -CH2R6, R1 is C1-C5 alkyl, C3-C7 cycloalkyl, allythio, styryl, phenoxymethyl, thienylmethyl, C6-C10 aryl optionally substituted, benzyl optionally substituted or 5- or 6-membered heterocyclic group optionally substituted, R2 and R3 each is hydrogen, C1-C5 alkyl, carboxy, C2-C5 alkoxycarbonyl or benzyloxycarbonyl optionally substituted, R4 and R5 each is hydrogen, C1-C5 alkyl, C3-C7 cycloalkyl or phenyl optionally substituted, and R8 is pyridyl or phenyl optionally substituted) being useful as antiulcer agents are provided through several routes.