NOVEL GLYCEROL DERIVATIVE, ITS PRODUCTION AND HYPOTENSOR CONTAINING THE SAME DERIVATIVE

摘要

NEW MATERIAL:The compound of formula I [R1 is 10-22C alkyl; R2 is 1-6C acyl or benzoyl; Y is nitrogen-containing heterocyclic group or nitrogen- containing condensed heterocyclic group containing a group of formual II (R3 is 1-6C alkyl) as a ring-forming group and optionally having alkyl, etc., as a substituent (the heterocyclic group is bonded to adjacent O via the C atom of the nitrogen-containing heterocyclic group, etc.); R4 to R6 are H, 1-6C alkyl, aryl or aralkyl]. EXAMPLE:2-Acetyloxy-3-hexadecyloxypropyl.1-methylpyridinio-3-yl phosphate. USE:A hypotensor. PREPARATION:A compound of formula III (e.g., 2-acetyloxy-3-hexadecyloxy- propanol) is made to react with a compound of formula IV (A- is anion) in the presence of a base (e.g., triethylamine).