Vaccine for generating an immunogenic T cell response protective against rabies virus

摘要

Vaccines which generate an immunogenic T cell response protective against a rabies virus disease state, comprise an immunologically effective amount of (1) a peptide-­fatty acid conjugate, (2) a liposome composition and (3) an adjuvant. The conjugate (1) has the formula where R′ and R˝ are alkyl groups containing 5 to 30 carbon atoms, and R‴ is selected from the group consisting of hydrogen and at least one amino acid residue, and X is an amino acid sequence corresponding to that of a peptide fragment derived from a protein of the virus which produces a T cell response, or a synthetic replica of said fragment.