Process for producing diadenosine tetraphosphate and derivatives thereof

摘要

A process for producing diadenosine tetraphosphate or derivatives thereof in very high yields with little formation of undesired by- products is disclosed. The process comprises reacting adenosine-5'- triphosphate or a derivative thereof with an amino acid under the catalytic action of an aminoacyl-tRNA synthetase in the presence of an enzyme that converts adenosine-5'-diphosphate to adenosine- 5'- triphosphate. The formation of by-products can be substantially completely inhibited if the last-mentioned enzyme is used in combination with an enzyme that converts adenosine-5'-monophosphate to adenosine-5'- diphosphate.