ISOINDOLINONE DERIVATIVE, CYTOCIDAL AGENT OF CERVICAL CARCINOMA CELL COMPRISING SAME DERIVATIVE AS ACTIVE INGREDIENT AND PRODUCTION SAME AGENT

摘要

NEW MATERIAL:6-[(2'E)-3',7'-Dimethyl-5'-oxo-2',6'-octadienyl]-7-hydroxyl-5- methoxy-N-(2''-phenylethyl)-1-isoindolinone. USE:A cytocidal agent of cervical carcinoma cell. PREPARATION:Fruit body of Hericium erinaceum, mushroom of the genus Hericium of the family Hydnaceae is extracted with a homogeneous system of water and an organic solvent. The organic solvent is evaporated from the treated solution thereof to give an aqueous phase, which is treated by liquid- liquid partition extraction in a mixed system of water and an organic solvent, an organic solvent layer is collected, the organic solvent is evaporated from the organic solvent layer to give the objective compound. A mixed system of water and chloroform is preferably used as the mixed system of water and the organic solvent. A substance prepared by evaporating the organic solvent from the organic solvent layer is preferably chromatographed and recrystallized further.